PPIP5K2

Across TCGA patient cohorts, PPIP5K2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIP5K2-associated genes across cancer lineages are HER3_pY1289, eEF2, and INPP4B. Each is linked with PPIP5K2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPIP5K2-to-partner and partner-to-PPIP5K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by PPIP5K2-low versus PPIP5K2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIP5K2→partner) and Y-score (partner→PPIP5K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER3_pY1289 →	+0.199	+2.186	<.001	.034	3	3
UCEC	eEF2 →	+0.297	+1.523	.009	.008	3	2
UCEC	INPP4B →	-0.270	-2.999	.009	<.001	3	2
UCEC	PCNA →	+0.162	+2.459	.018	.018	3	2
UCEC	Annexin-1 →	+0.389	+1.827	.020	.015	3	2
UCEC	S6_pS240_S244 →	+0.262	+1.523	.043	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

HER3_pY1289 by PPIP5K2 expression — SKCM

Explore this box plot interactively →