PPIP5K2

Across TCGA cell cohorts, PPIP5K2 mutation is significantly associated with the RNA expression of many other genes, with 217 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPIP5K2-associated genes across cancer lineages are USP17L17, SIGLEC7, and CRYAA. Each is linked with PPIP5K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIP5K2-to-partner and partner-to-PPIP5K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L17 grouped by PPIP5K2-low versus PPIP5K2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIP5K2→partner) and Y-score (partner→PPIP5K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	USP17L17 →	+0.013	+5.807	<.001	.001	3	2
OESOPHAGUS	SIGLEC7 →	+0.063	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUSC	CRYAA →	+0.039	+4.108	<.001	.005	3	1
BLOOD_Leukemia	MYL10 →	+0.015	+4.247	<.001	.004	3	1
BLOOD_Leukemia	AGXT2 →	+0.002	+4.247	<.001	.004	3	1
BLOOD_Leukemia	GC →	+0.097	+3.106	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 217 associations by consensus.

USP17L17 by PPIP5K2 expression — OVARY

Explore this box plot interactively →