Across TCGA cell cohorts, PPIL6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPIL6-associated genes across cancer lineages are MAGEB4, STRA8, and ZNF804B. Each is linked with PPIL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIL6-to-partner and partner-to-PPIL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL6→partner) and Y-score (partner→PPIL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ZNF804B →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DBX2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.336	+5.415	<.001	.004	3	1
OVARY	KRTAP4-2 →	+0.028	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

PPIL6 survival (RNA) · tumor vs normal (RNA) · all PPIL6 data types