PPIL4

Across TCGA cell cohorts, PPIL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,665 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPIL4-associated GO terms across cancer lineages are Negative regulation of ubiquitin protein ligase activity, 7-methylguanosine mRNA capping, and 7-methylguanosine RNA capping. Each is linked with PPIL4 in more than 15 cancer types. Because this analysis shows association rather than direction, both PPIL4-to-partner and partner-to-PPIL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ubiquitin protein ligase activity grouped by PPIL4-low versus PPIL4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL4→partner) and Y-score (partner→PPIL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of ubiquitin protein ligase activity →	+0.226	+0.899	<.001	<.001	3	16
OVARY	7-methylguanosine mRNA capping →	+0.109	+0.714	<.001	<.001	3	15
OVARY	7-methylguanosine RNA capping →	+0.109	+0.714	<.001	<.001	3	15
BLOOD_Myeloma	Regulation of termination of RNA polymerase II transcription →	+0.113	+1.232	.002	<.001	3	14
BREAST	Regulation of termination of RNA polymerase II transcription, poly(A)-coupled →	+0.103	+0.683	.001	<.001	3	14
BLOOD_Myeloma	Regulation of termination of DNA-templated transcription →	+0.113	+1.232	.002	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,665 associations by consensus.

Negative regulation of ubiquitin protein ligase activity by PPIL4 expression — LUNG_NSCLC_LUSC

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