PPIL2

Across TCGA patient cohorts, PPIL2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,267 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPIL2-associated genes across cancer lineages are UBE2L3, GUCD1, and THAP7. Each is linked with PPIL2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PPIL2-to-partner and partner-to-PPIL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPIL2 versus UBE2L3 in HNSC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL2→partner) and Y-score (partner→PPIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UBE2L3 →	+0.496	+0.267	<.001	<.001	3	6
HNSC	GUCD1 →	+0.765	+0.193	.002	<.001	3	5
HNSC	THAP7 →	+0.783	+0.204	.002	<.001	3	5
HNSC	UFD1 →	+0.754	+0.257	<.001	<.001	3	5
HNSC	TRMT2A →	+0.793	+0.191	.001	.001	3	5
LSCC	RTL10 →	+0.652	+0.292	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,267 associations by consensus.

PPIL2 vs UBE2L3 — HNSC

Explore this scatter interactively →