PPIL2

Across TCGA patient cohorts, PPIL2 mutation is significantly associated with the RNA expression of many other genes, with 4,983 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIL2-associated genes across cancer lineages are DDX41, ATAD3A, and MNT. Each is linked with PPIL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPIL2-to-partner and partner-to-PPIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX41 grouped by PPIL2-low versus PPIL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL2→partner) and Y-score (partner→PPIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DDX41 →	+0.403	+2.813	.002	.001	3	3
UCEC	ATAD3A →	+0.517	+4.032	<.001	<.001	3	3
UCEC	MNT →	+0.298	+2.095	.008	.003	3	3
UCEC	MIR4324 →	+0.645	+1.620	.001	.006	3	3
UCEC	ICMT →	+0.397	+3.871	.001	<.001	3	3
UCEC	CLN6 →	+0.317	+2.168	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,983 associations by consensus.

DDX41 by PPIL2 expression — SKCM

Explore this box plot interactively →