PPIL2

Across TCGA patient cohorts, PPIL2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIL2-associated genes across cancer lineages are A-Raf_pS299, BRD4, and Caspase-7-cleavedD198. Each is linked with PPIL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIL2-to-partner and partner-to-PPIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PPIL2-low versus PPIL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL2→partner) and Y-score (partner→PPIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.140	-3.584	.001	.002	3	2
UCEC	BRD4 →	+0.229	+2.999	.022	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.967	+2.999	<.001	<.001	3	2
UCEC	CD49b →	-0.295	-3.308	.003	.009	3	2
UCEC	C-Raf →	+0.190	+2.321	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.116	-3.673	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

A-Raf_pS299 by PPIL2 expression — UCEC

Explore this box plot interactively →