PPIL2

Across TCGA cell cohorts, PPIL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,898 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPIL2-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Interleukin-34-mediated signaling pathway. Each is linked with PPIL2 in more than 18 cancer types. Because this analysis shows association rather than direction, both PPIL2-to-partner and partner-to-PPIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by PPIL2-low versus PPIL2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL2→partner) and Y-score (partner→PPIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Symbiont-mediated disruption of host cellular anatomical structure →	+0.175	+1.040	<.001	<.001	3	19
KIDNEY	Symbiont-mediated disruption of host anatomical structure →	+0.175	+1.040	<.001	<.001	3	19
KIDNEY	Interleukin-34-mediated signaling pathway →	+0.217	+0.689	.008	.007	3	15
LIVER	DNA topological change →	+0.176	+1.325	.001	.001	3	14
KIDNEY	Regulation of macrophage proliferation →	+0.257	+0.812	.002	.002	3	13
KIDNEY	Positive regulation of macrophage proliferation →	+0.242	+0.806	.002	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,898 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by PPIL2 expression — KIDNEY

Explore this box plot interactively →