PPIL2

Across TCGA cell cohorts, PPIL2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPIL2-associated genes across cancer lineages are ADRA1A, OR11H6, and OR13D1. Each is linked with PPIL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIL2-to-partner and partner-to-PPIL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by PPIL2-low versus PPIL2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL2→partner) and Y-score (partner→PPIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADRA1A →	+0.021	+4.196	<.001	.002	3	2
SOFT_TISSUE	OR11H6 →	+0.028	+4.930	<.001	.008	3	2
URINARY_TRACT	OR13D1 →	+0.026	+4.217	<.001	.005	3	1
SKIN	IFNG →	+0.016	+4.437	<.001	.004	3	1
SKIN	PGLYRP2 →	+0.143	+4.217	<.001	.001	3	1
LARGE_INTESTINE	PITX3 →	+0.178	+3.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ADRA1A by PPIL2 expression — SKIN

Explore this box plot interactively →