PPIL1

Across TCGA patient cohorts, PPIL1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIL1-associated genes across cancer lineages are EGFR_pY1068, Myosin-IIa_pS1943, and Myosin-IIa. Each is linked with PPIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIL1-to-partner and partner-to-PPIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PPIL1-low versus PPIL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIL1→partner) and Y-score (partner→PPIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.272	-3.000	.020	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.267	+1.887	.005	.031	3	1
UCEC	Myosin-IIa →	+0.332	+2.821	<.001	.034	3	1
UCEC	PI3K-p85 →	+0.217	+2.179	.025	.034	3	1
UCEC	SF2 →	-0.176	-2.311	<.001	.034	3	1
UCEC	ARID1A →	-0.197	-3.577	.024	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by PPIL1 expression — UCEC

Explore this box plot interactively →