PPIH

Across TCGA pan-cancer cohorts, PPIH mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPIH data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPIH mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPIH expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where PPIH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.638	0.443	.001	10	view →
HNSC	DFS	Tertile	IV	0.561	0.819	.023	8	view →
LSCC	DFS	Median	All	1.000	0.905	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PPIH–PDAC (OS)

Open the PDAC breakdown →