PPIH

Across TCGA pan-cancer cohorts, PPIH mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PPIH’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PPIH mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPIH is over-expressed in tumor.

CCRCC, COAD, and LUAD are the cancer types where PPIH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.281	<.001	10	view →
COAD	Male	III,IV	+0.366	<.001	9	view →
LUAD	Male	III,IV	+0.358	<.001	9	view →
LSCC	Male	All	+0.300	<.001	8	view →
HNSC	All	II,III,IV	+0.110	.002	8	view →
OV	All	All	+0.591	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PPIH–CCRCC

Open the CCRCC breakdown →