PPIH

Across TCGA patient cohorts, PPIH protein abundance is significantly associated with the RNA expression of many other genes, with 10,480 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPIH-associated genes across cancer lineages are ZFP69B, C1orf112, and SCN1B. Each is linked with PPIH in more than 7 cancer types. Because this analysis shows association rather than direction, both PPIH-to-partner and partner-to-PPIH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPIH versus ZFP69B in LSCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIH→partner) and Y-score (partner→PPIH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZFP69B →	+0.782	+0.245	<.001	.002	3	8
HNSC	C1orf112 →	+0.647	+0.181	<.001	.001	3	7
GBM	SCN1B →	-0.916	-0.208	<.001	<.001	3	6
UCEC	DPH2 →	+0.744	+0.237	<.001	<.001	3	6
LSCC	NASP →	+0.743	+0.282	<.001	<.001	3	6
BRCA	CDCA8 →	+1.107	+0.340	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,480 associations by consensus.

PPIH vs ZFP69B — LSCC

Explore this scatter interactively →