PPIH

Across TCGA patient cohorts, PPIH mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIH-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Acetyl-a-Tubulin-Lys40. Each is linked with PPIH in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIH-to-partner and partner-to-PPIH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PPIH-low versus PPIH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIH→partner) and Y-score (partner→PPIH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.282	-2.321	.025	.035	3	1
UCEC	ERK2 →	+0.271	+2.321	.005	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.561	+2.179	.028	.034	3	1
UCEC	JNK2 →	+0.360	+2.321	<.001	.035	3	1
UCEC	MSH2 →	-0.253	-2.321	.029	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.205	+2.335	.048	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1068 by PPIH expression — UCEC

Explore this box plot interactively →