PPIH

Across TCGA cell cohorts, PPIH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,148 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPIH-associated GO terms across cancer lineages are DNA replication initiation, Meiotic sister chromatid cohesion, and Spindle elongation. Each is linked with PPIH in more than 16 cancer types. Because this analysis shows association rather than direction, both PPIH-to-partner and partner-to-PPIH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by PPIH-low versus PPIH-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIH→partner) and Y-score (partner→PPIH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication initiation →	+0.232	+0.996	<.001	<.001	3	17
STOMACH	Meiotic sister chromatid cohesion →	+0.145	+0.813	<.001	.002	3	16
KIDNEY	Spindle elongation →	+0.228	+0.814	.005	.001	3	16
STOMACH	Negative regulation of mitotic sister chromatid separation →	+0.158	+0.712	.001	.003	3	16
STOMACH	Negative regulation of sister chromatid segregation →	+0.158	+0.712	.001	.003	3	16
KIDNEY	Regulation of mitotic sister chromatid segregation →	+0.111	+0.629	.006	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,148 associations by consensus.

DNA replication initiation by PPIH expression — BONE

Explore this box plot interactively →