PPIG

Across TCGA cell cohorts, PPIG RNA expression is significantly associated with the go_rna of many other GO terms, with 3,714 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPIG-associated GO terms across cancer lineages are Replication fork processing, DNA-templated DNA replication maintenance of fidelity, and Centrosome duplication. Each is linked with PPIG in more than 18 cancer types. Because this analysis shows association rather than direction, both PPIG-to-partner and partner-to-PPIG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Replication fork processing grouped by PPIG-low versus PPIG-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIG→partner) and Y-score (partner→PPIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Replication fork processing →	+0.095	+0.737	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.095	+0.755	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Centrosome duplication →	+0.108	+0.888	<.001	.001	3	17
BONE	Nuclear pore organization →	+0.175	+0.604	.005	.002	3	17
UPPER_AERODIGESTIVE_TRACT	Mitotic cell cycle checkpoint signaling →	+0.130	+0.970	<.001	<.001	3	17
BLOOD_Myeloma	Negative regulation of cell cycle process →	+0.065	+0.950	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,714 associations by consensus.

Replication fork processing by PPIG expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →