PPIG

Across TCGA cell cohorts, PPIG mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPIG-associated genes across cancer lineages are NPSR1, MS4A10, and PCDH11X. Each is linked with PPIG in more than 2 cancer types. Because this analysis shows association rather than direction, both PPIG-to-partner and partner-to-PPIG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPSR1 grouped by PPIG-low versus PPIG-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIG→partner) and Y-score (partner→PPIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NPSR1 →	+0.036	+3.453	<.001	.009	3	3
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
BLOOD_Leukemia	PCDH11X →	+0.162	+4.275	<.001	.006	3	1
BLOOD_Leukemia	SLC22A7 →	+0.055	+3.944	<.001	.006	3	1
BLOOD_Leukemia	HCN4 →	+0.056	+3.855	<.001	.007	3	1
BLOOD_Leukemia	BTNL3 →	+0.224	+3.774	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

NPSR1 by PPIG expression — SKIN

Explore this box plot interactively →