PPIC

Across TCGA patient cohorts, PPIC mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIC-associated genes across cancer lineages are ACVRL1, VHL, and c-Met_pY1235. Each is linked with PPIC in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIC-to-partner and partner-to-PPIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by PPIC-low versus PPIC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIC→partner) and Y-score (partner→PPIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.162	-3.321	.023	.010	3	1
UCEC	VHL →	-1.267	-3.321	<.001	.010	3	1
UCEC	c-Met_pY1235 →	+0.084	+3.321	.030	.010	3	1
UCEC	Tuberin →	+0.420	+2.817	.002	.036	2	1
UCEC	Rab11 →	-0.152	-3.321	.046	.010	1	1
UCEC	Caspase-8 →	-0.343	-3.321	.009	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ACVRL1 by PPIC expression — UCEC

Explore this box plot interactively →