PPIC

Across TCGA cell cohorts, PPIC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,539 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPIC-associated GO terms across cancer lineages are Cotranslational protein targeting to membrane, Endoplasmic reticulum to cytosol transport, and Retrograde protein transport, ER to cytosol. Each is linked with PPIC in more than 11 cancer types. Because this analysis shows association rather than direction, both PPIC-to-partner and partner-to-PPIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cotranslational protein targeting to membrane grouped by PPIC-low versus PPIC-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIC→partner) and Y-score (partner→PPIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cotranslational protein targeting to membrane →	+0.125	+3.278	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Endoplasmic reticulum to cytosol transport →	+0.144	+1.023	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Retrograde protein transport, ER to cytosol →	+0.144	+1.023	<.001	<.001	3	12
LIVER	Regulation of proteasomal protein catabolic process →	+0.055	+1.457	.007	.003	3	12
LUNG_SCLC	Protein folding →	+0.079	+2.460	<.001	.001	3	11
BONE	Glycolipid catabolic process →	+0.241	+5.071	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,539 associations by consensus.

Cotranslational protein targeting to membrane by PPIC expression — BONE

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