PPIC-AS1

Across TCGA pan-cancer cohorts, PPIC-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PPIC-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher PPIC-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPIC-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

UVM, LGG, and UCEC are the cancer types where PPIC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.419	0.861	<.001	70	view →
LGG	DFS	Median	All	0.287	0.486	<.001	52	view →
UCEC	OS	Quartile	II,III,IV	0.641	0.869	.001	46	view →
KIRC	DFS	Median	IV	0.613	0.296	.010	35	view →
THCA	OS	Median	All	0.799	1.000	.004	31	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	22	view →
MESO	OS	Tertile	II,III,IV	0.605	0.222	.012	12	view →
OV	DFS	Quartile	III,IV	0.474	0.581	.023	12	view →
COAD	OS	Median	IV	0.819	0.432	.017	12	view →
SKCM	DFS	Quartile	All	0.652	0.799	.015	11	view →
BLCA	DFS	Median	All	0.233	0.468	.036	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PPIC-AS1–UVM (DFS)

Open the UVM breakdown →