PPIB

Across TCGA pan-cancer cohorts, PPIB Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPIB data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PPIB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPIB expression acts as an unfavorable survival marker.

THYM, SKCM, and SARC are the cancer types where PPIB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
SKCM	OS	Median	III,IV	0.138	0.841	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PPIB–THYM (OS)

Open the THYM breakdown →