PPIB

Across TCGA pan-cancer cohorts, PPIB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPIB data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPIB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPIB expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where PPIB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.202	0.985	.007	20	view →
LSCC	DFS	Tertile	II,III,IV	0.451	0.910	.001	12	view →
HNSC	OS	Median	All	0.957	1.000	.017	6	view →
UCEC	DFS	Median	All	0.921	0.795	.038	4	view →
PDAC	DFS	Quartile	II,III,IV	0.853	0.652	.006	4	view →
GBM	DFS	Tertile	All	0.248	0.437	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPIB–CCRCC (OS)

Open the CCRCC breakdown →