Across TCGA pan-cancer cohorts, PPIAP79 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPIAP79’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPIAP79 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIAP79 is over-expressed in tumor, although a few such as PAAD and KICH show the opposite, repressed pattern.
HNSC, PAAD, and KICH are the cancer types where PPIAP79 tumor–normal differential expression is most reproducible.