Across TCGA pan-cancer cohorts, PPIAP74 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPIAP74’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPIAP74 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIAP74 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BRCA, and KIRC are the cancer types where PPIAP74 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIAP74 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.157	.013	2	view →
BRCA	All	All	+0.065	.017	2	view →
KIRC	All	All	+0.057	.028	2	view →
THCA	All	IV	−0.180	.039	1	view →
KICH	Female	III,IV	+0.170	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PPIAP74 RNA expression & survival · all PPIAP74 data types