Across TCGA pan-cancer cohorts, PPIAP53 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PPIAP53 data layer.
The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PPIAP53 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPIAP53 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.
ACC, BLCA, and BRCA are the cancer types where PPIAP53 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.