PPIAP47

Across TCGA pan-cancer cohorts, PPIAP47 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PPIAP47’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PPIAP47 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIAP47 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUSC, BLCA, and COAD are the cancer types where PPIAP47 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIAP47 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+0.249	<.001	7	view →
BLCA	Female	IV	+0.300	.023	6	view →
COAD	All	All	+0.207	<.001	6	view →
HNSC	Male	All	+0.166	.001	6	view →
LUAD	All	All	+0.162	<.001	6	view →
BRCA	Female	II,III,IV	+0.103	<.001	6	view →
KIRC	All	II,III,IV	+0.083	.004	6	view →
LIHC	All	All	+0.052	.010	4	view →
UCEC	All	II,III,IV	+0.430	.023	2	view →
KICH	Male	III,IV	−0.180	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PPIAP47–LUSC

Open the LUSC breakdown →