PPIAP46

Across TCGA pan-cancer cohorts, PPIAP46 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PPIAP46 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PPIAP46 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPIAP46 expression acts as an unfavorable survival marker, although some lineages such as MESO and LIHC show a favorable association.

LGG, STAD, and COAD are the cancer types where PPIAP46 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Tertile	All	0.626	0.797	<.001	48	view →
STAD	DFS	Quartile	All	0.562	0.740	.005	41	view →
COAD	DFS	Median	All	0.423	0.601	.001	30	view →
MESO	DFS	Median	All	0.476	0.300	.006	27	view →
LIHC	OS	Tertile	All	0.657	0.325	<.001	25	view →
KIRC	DFS	Quartile	IV	0.415	0.652	.010	14	view →
ACC	OS	Quartile	IV	0.876	0.361	.006	13	view →
LUSC	OS	Median	II,III,IV	0.696	0.529	.005	12	view →
PAAD	DFS	Median	All	0.231	0.434	.005	10	view →
READ	OS	Median	IV	0.511	0.878	.008	10	view →
UCS	DFS	Tertile	III,IV	0.488	0.134	.023	6	view →
CHOL	DFS	Median	III,IV	0.133	0.779	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PPIAP46–LGG (DFS)

Open the LGG breakdown →