PPIAP45

Across TCGA pan-cancer cohorts, PPIAP45 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated PPIAP45 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PPIAP45 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PPIAP45 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, MESO, and ACC are the cancer types where PPIAP45 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.428	0.265	<.001	139	view →
MESO	OS	Median	II,III,IV	0.283	0.495	.002	91	view →
ACC	OS	Tertile	II,III,IV	0.710	0.921	.001	50	view →
KIRP	DFS	Quartile	All	0.746	0.890	.003	37	view →
BLCA	OS	Tertile	III,IV	0.703	0.516	.011	34	view →
READ	OS	Tertile	III,IV	1.000	0.773	.001	32	view →
LGG	DFS	Quartile	All	0.638	0.767	.001	24	view →
CESC	DFS	Tertile	All	0.876	0.750	.004	22	view →
UCEC	OS	Tertile	IV	0.631	0.306	.007	22	view →
KIRC	DFS	Quartile	IV	0.259	0.590	.012	20	view →
UVM	OS	Tertile	All	0.414	0.784	.027	14	view →
KICH	DFS	Median	IV	0.317	0.923	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

PPIAP45–SKCM (OS)

Open the SKCM breakdown →