PPIAP39

Across TCGA pan-cancer cohorts, PPIAP39 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPIAP39’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PPIAP39 RNA is repressed in tumor relative to normal tissue. In most cancer types PPIAP39 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and LUAD are the cancer types where PPIAP39 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIAP39 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−2.026	<.001	11	view →
BRCA	All	II,III,IV	−2.543	<.001	8	view →
LUAD	Female	III,IV	−1.776	<.001	8	view →
BLCA	Male	All	−1.705	<.001	8	view →
LUSC	Female	II,III,IV	−3.217	<.001	7	view →
UCEC	All	All	−1.914	<.001	6	view →
KICH	All	All	−0.750	<.001	6	view →
KIRP	All	All	−0.534	<.001	5	view →
COAD	All	All	+0.350	.003	5	view →
STAD	Female	All	+0.620	.011	2	view →
CHOL	All	All	+0.592	.026	1	view →
LIHC	All	All	+0.362	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPIAP39–THCA

Open the THCA breakdown →