PPIAL4F

Across TCGA pan-cancer cohorts, PPIAL4F RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated PPIAL4F data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher PPIAL4F RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPIAL4F expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUSC show a favorable association.

DLBC, LIHC, and KICH are the cancer types where PPIAL4F RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	All	0.446	0.868	.005	68	view →
LIHC	DFS	Tertile	II,III,IV	0.220	0.452	.003	54	view →
KICH	OS	Tertile	III,IV	0.162	0.763	<.001	36	view →
SCLC	OS	Quartile	All	0.616	0.220	.004	27	view →
ACC	OS	Tertile	III,IV	0.283	0.622	.039	27	view →
LUSC	OS	Tertile	II,III,IV	0.895	0.696	.013	21	view →
COAD	DFS	Tertile	IV	0.035	0.501	<.001	18	view →
LUAD	DFS	Tertile	IV	0.456	0.745	.033	18	view →
LGG	OS	Tertile	All	0.655	0.848	.013	15	view →
PAAD	OS	Tertile	II,III,IV	1.000	0.408	.024	12	view →
OV	DFS	Tertile	II,III,IV	0.197	0.126	.028	12	view →
THCA	DFS	Tertile	IV	0.604	0.963	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

PPIAL4F–DLBC (DFS)

Open the DLBC breakdown →