Across TCGA pan-cancer cohorts, PPIA Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPIA data layer compared with 26 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPIA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPIA expression acts as an unfavorable survival marker.

HNSC, READ, and ACC are the cancer types where PPIA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.751	<.001	48	view →
READ	OS	Median	All	0.183	0.828	<.001	12	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PPIA tumor-vs-normal RNA expression · all PPIA data types