Across TCGA cell cohorts, PPIA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,425 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PPIA-associated GO terms across cancer lineages are Dihydrofolate metabolic process, Regulation of mitotic sister chromatid separation, and Negative regulation of metaphase/anaphase transition of cell cycle. Each is linked with PPIA in more than 13 cancer types. Because this analysis shows association rather than direction, both PPIA-to-partner and partner-to-PPIA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIA→partner) and Y-score (partner→PPIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Dihydrofolate metabolic process →	+0.249	+1.140	<.001	<.001	3	14
BLOOD_Lymphoma	Regulation of mitotic sister chromatid separation →	+0.101	+0.902	.003	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.137	+0.961	.002	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome separation →	+0.137	+0.961	.002	<.001	3	10
SKIN	Centromeric sister chromatid cohesion →	+0.125	+0.620	<.001	<.001	3	10
CNS	Positive regulation of metaphase/anaphase transition of cell cycle →	+0.109	+0.462	.001	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,425 associations by consensus.

Exploration

PPIA survival (RNA) · tumor vs normal (RNA) · all PPIA data types