PPHLN1

Across TCGA pan-cancer cohorts, PPHLN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPHLN1 data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPHLN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPHLN1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, GBM, and PDAC are the cancer types where PPHLN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.109	1.000	.017	18	view →
GBM	OS	Quartile	All	0.551	0.313	.016	4	view →
PDAC	OS	Tertile	II,III,IV	0.288	0.521	.040	4	view →
CCRCC	OS	Median	All	0.903	0.984	.027	3	view →
LSCC	DFS	Median	II,III,IV	0.822	0.578	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPHLN1–HNSC (OS)

Open the HNSC breakdown →