PPHLN1

Across TCGA patient cohorts, PPHLN1 mutation is significantly associated with the RNA expression of many other genes, with 1,441 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPHLN1-associated genes across cancer lineages are RNU6-1318P, TUBGCP5, and LINC00869. Each is linked with PPHLN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPHLN1-to-partner and partner-to-PPHLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1318P grouped by PPHLN1-low versus PPHLN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPHLN1→partner) and Y-score (partner→PPHLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1318P →	+0.263	+4.292	<.001	.001	3	3
UCEC	TUBGCP5 →	+0.402	+2.332	.001	.003	3	2
UCEC	LINC00869 →	-0.573	-2.874	<.001	.001	3	2
READ	CSH2 →	+0.035	+5.925	<.001	.002	3	2
COAD	TRIM7 →	+1.336	+3.335	<.001	.005	3	2
COAD	PPP2R2D →	+0.278	+3.402	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,441 associations by consensus.

RNU6-1318P by PPHLN1 expression — SKCM

Explore this box plot interactively →