PPHLN1

Across TCGA patient cohorts, PPHLN1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPHLN1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Caspase-8. Each is linked with PPHLN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPHLN1-to-partner and partner-to-PPHLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PPHLN1-low versus PPHLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPHLN1→partner) and Y-score (partner→PPHLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.476	-1.415	.005	.046	3	3
UCEC	Caspase-7-cleavedD198 →	+0.606	+2.135	.006	.010	3	2
UCEC	Caspase-8 →	-0.267	-3.558	.004	.002	3	2
UCEC	ERK2 →	+0.167	+2.321	.020	.033	3	1
UCEC	FASN →	+0.398	+1.415	.007	.046	3	1
UCEC	GAPDH →	+0.451	+1.874	.025	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by PPHLN1 expression — UCEC

Explore this box plot interactively →