PPFIBP2

Across TCGA pan-cancer cohorts, PPFIBP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPFIBP2 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPFIBP2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPFIBP2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where PPFIBP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.681	0.399	<.001	134	view →
HNSC	DFS	Quartile	All	0.939	0.692	.004	17	view →
CCRCC	DFS	Quartile	III,IV	0.662	0.232	.008	15	view →
COAD	DFS	Median	All	1.000	0.930	.025	12	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.439	.003	12	view →
LUAD	OS	Median	All	1.000	0.793	.014	4	view →
GBM	OS	Median	All	0.392	0.632	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPFIBP2–PDAC (OS)

Open the PDAC breakdown →