PPFIBP2

Across TCGA patient cohorts, PPFIBP2 mutation is significantly associated with the RNA expression of many other genes, with 4,378 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIBP2-associated genes across cancer lineages are PSMC3IP, OXSM, and CXXC1. Each is linked with PPFIBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPFIBP2-to-partner and partner-to-PPFIBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by PPFIBP2-low versus PPFIBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIBP2→partner) and Y-score (partner→PPFIBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.835	+2.180	<.001	<.001	3	3
UCEC	OXSM →	+0.293	+1.823	.001	.007	3	3
UCEC	CXXC1 →	+0.407	+4.000	<.001	<.001	3	3
UCEC	GNL3 →	+0.356	+2.177	.007	.001	3	3
UCEC	SAAL1 →	+0.574	+1.914	<.001	<.001	3	3
LUAD	MIR3926-1 →	+0.588	+4.010	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,378 associations by consensus.

PSMC3IP by PPFIBP2 expression — UCEC

Explore this box plot interactively →