PPFIBP2

Across TCGA patient cohorts, PPFIBP2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIBP2-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and FoxM1. Each is linked with PPFIBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPFIBP2-to-partner and partner-to-PPFIBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PPFIBP2-low versus PPFIBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIBP2→partner) and Y-score (partner→PPFIBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.084	-2.195	.011	.009	3	2
UCEC	eIF4E →	+0.198	+3.820	.004	<.001	3	2
UCEC	FoxM1 →	+0.297	+2.263	<.001	<.001	3	2
UCEC	INPP4B →	-0.263	-1.999	.013	.008	3	2
UCEC	Ku80 →	+0.302	+2.276	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.135	-1.392	.006	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

14-3-3_beta by PPFIBP2 expression — UCEC

Explore this box plot interactively →