PPFIBP2

Across TCGA cell cohorts, PPFIBP2 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPFIBP2-associated genes across cancer lineages are FCN2, RTP1, and GPX5. Each is linked with PPFIBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPFIBP2-to-partner and partner-to-PPFIBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by PPFIBP2-low versus PPFIBP2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIBP2→partner) and Y-score (partner→PPFIBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FCN2 →	+0.033	+5.087	<.001	.004	3	2
LARGE_INTESTINE	RTP1 →	+0.153	+4.082	.003	<.001	3	2
LARGE_INTESTINE	GPX5 →	+0.226	+2.688	<.001	.008	3	2
KIDNEY	H2BW1 →	+0.073	+4.491	<.001	.002	3	1
KIDNEY	AQP10 →	+0.014	+4.491	<.001	.002	3	1
KIDNEY	OR1N2 →	+0.030	+4.954	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

FCN2 by PPFIBP2 expression — URINARY_TRACT

Explore this box plot interactively →