PPFIA4

Across TCGA patient cohorts, PPFIA4 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIA4-associated genes across cancer lineages are ATM, eEF2, and Smad1. Each is linked with PPFIA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPFIA4-to-partner and partner-to-PPFIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PPFIA4-low versus PPFIA4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA4→partner) and Y-score (partner→PPFIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.686	-3.450	<.001	.005	3	3
UCEC	eEF2 →	+0.345	+1.662	.001	.010	3	3
SKCM	Smad1 →	-0.139	-2.321	.016	.033	3	3
LUSC	PI3K-p85 →	-0.176	-3.450	.014	.005	3	2
COAD	GATA6 →	-0.217	-3.000	.015	.033	3	2
COAD	INPP4B →	-0.478	-3.000	.004	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

ATM by PPFIA4 expression — COAD

Explore this box plot interactively →