PPFIA4

Across TCGA cell cohorts, PPFIA4 mutation is significantly associated with the RNA expression of many other genes, with 455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPFIA4-associated genes across cancer lineages are MTRNR2L10, ZSCAN1, and TBL1Y. Each is linked with PPFIA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPFIA4-to-partner and partner-to-PPFIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L10 grouped by PPFIA4-low versus PPFIA4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA4→partner) and Y-score (partner→PPFIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MTRNR2L10 →	+0.008	+4.357	<.001	.004	3	2
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
OESOPHAGUS	PIP →	+0.121	+3.584	<.001	.008	3	1
LUNG_SCLC	OR6C70 →	+0.033	+5.643	<.001	.002	3	1
LARGE_INTESTINE	SLC25A1 →	+0.726	+2.628	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 455 associations by consensus.

MTRNR2L10 by PPFIA4 expression — CNS

Explore this box plot interactively →