PPFIA3

Across TCGA patient cohorts, PPFIA3 mutation is significantly associated with the RNA expression of many other genes, with 1,540 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIA3-associated genes across cancer lineages are POLE2, CDKN3, and CD207. Each is linked with PPFIA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPFIA3-to-partner and partner-to-PPFIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by PPFIA3-low versus PPFIA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA3→partner) and Y-score (partner→PPFIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE2 →	+0.473	+2.721	.003	.003	3	3
UCEC	CDKN3 →	+0.680	+2.470	.001	<.001	3	3
UCEC	CD207 →	-0.845	-3.689	<.001	.001	3	3
UCEC	LARP1B →	+0.529	+2.124	<.001	<.001	3	3
UCEC	PRPSAP2 →	+0.366	+2.137	.009	.009	3	3
UCEC	CIDECP1 →	+0.522	+2.124	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,540 associations by consensus.

POLE2 by PPFIA3 expression — UCEC

Explore this box plot interactively →