PPFIA3

Across TCGA patient cohorts, PPFIA3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIA3-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, EGFR_pY1068, and FoxM1. Each is linked with PPFIA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPFIA3-to-partner and partner-to-PPFIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by PPFIA3-low versus PPFIA3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA3→partner) and Y-score (partner→PPFIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Acetyl-a-Tubulin-Lys40 →	-0.690	-3.000	.009	.033	3	3
UCEC	EGFR_pY1068 →	-0.339	-2.584	<.001	.001	3	2
UCEC	FoxM1 →	+0.214	+2.087	.031	.005	3	2
UCEC	MEK1 →	+0.422	+4.000	.002	<.001	3	2
UCEC	Rictor_pT1135 →	-0.081	-3.169	.039	.018	3	2
UCEC	STAT3_pY705 →	-0.401	-2.222	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Acetyl-a-Tubulin-Lys40 by PPFIA3 expression — CESC

Explore this box plot interactively →