PPFIA3

Across TCGA cell cohorts, PPFIA3 mutation is significantly associated with the RNA expression of many other genes, with 974 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPFIA3-associated genes across cancer lineages are INO80E, CCR8, and PES1. Each is linked with PPFIA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPFIA3-to-partner and partner-to-PPFIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INO80E grouped by PPFIA3-low versus PPFIA3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA3→partner) and Y-score (partner→PPFIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	INO80E →	+0.394	+3.234	<.001	.004	3	3
OVARY	CCR8 →	+0.169	+4.070	<.001	.003	3	2
LARGE_INTESTINE	PES1 →	+0.528	+3.537	.004	.001	3	2
LARGE_INTESTINE	RBFA →	+0.885	+3.364	<.001	.002	2	3
LARGE_INTESTINE	SUFU →	+0.601	+3.364	.001	.002	3	2
LARGE_INTESTINE	UFSP2 →	+0.630	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 974 associations by consensus.

INO80E by PPFIA3 expression — LARGE_INTESTINE

Explore this box plot interactively →