PPFIA2

Across TCGA pan-cancer cohorts, PPFIA2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPFIA2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPFIA2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPFIA2 is over-expressed in tumor, although a few such as LSCC and CCRCC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where PPFIA2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPFIA2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+1.578	.002	5	view →
PDAC	Male	All	+0.680	.002	4	view →
LSCC	All	All	−0.760	.001	2	view →
CCRCC	Female	All	−1.040	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PPFIA2–HNSC

Open the HNSC breakdown →