PPFIA2

Across TCGA patient cohorts, PPFIA2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,967 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPFIA2-associated genes across cancer lineages are PPFIA2-AS1, ZNF423, and SEPTIN4. Each is linked with PPFIA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPFIA2-to-partner and partner-to-PPFIA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPFIA2 versus PPFIA2-AS1 in GBM, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA2→partner) and Y-score (partner→PPFIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPFIA2-AS1 →	+0.789	+0.735	<.001	<.001	3	4
CCRCC	ZNF423 →	+0.814	+0.733	.006	<.001	3	3
CCRCC	SEPTIN4 →	+1.162	+0.763	<.001	.004	3	3
CCRCC	DCN →	+2.670	+0.783	<.001	.003	3	3
CCRCC	TGFB3 →	+0.912	+0.823	.001	.001	3	3
CCRCC	MCF2L →	+0.819	+0.803	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,967 associations by consensus.

PPFIA2 vs PPFIA2-AS1 — GBM

Explore this scatter interactively →