PPFIA2

Across TCGA patient cohorts, PPFIA2 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPFIA2-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with PPFIA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPFIA2-to-partner and partner-to-PPFIA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PPFIA2-low versus PPFIA2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA2→partner) and Y-score (partner→PPFIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.421	-3.169	.004	.017	3	4
COAD	Caspase-7-cleavedD198 →	+1.191	+2.338	<.001	.017	3	4
COAD	Cyclin-B1 →	+0.557	+3.016	.007	.018	3	4
UCEC	eEF2 →	+0.210	+1.514	.014	.012	3	3
COAD	eIF4E →	+0.171	+2.334	.011	.018	3	3
COAD	HER2_pY1248 →	-0.191	-2.309	.042	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ATM by PPFIA2 expression — COAD

Explore this box plot interactively →