PPFIA2

Across TCGA cell cohorts, PPFIA2 mutation is significantly associated with the RNA expression of many other genes, with 882 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPFIA2-associated genes across cancer lineages are TRIM16L, MDH1B, and AP1AR. Each is linked with PPFIA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPFIA2-to-partner and partner-to-PPFIA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM16L grouped by PPFIA2-low versus PPFIA2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPFIA2→partner) and Y-score (partner→PPFIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIM16L →	+1.685	+3.459	<.001	.001	3	2
LUNG_NSCLC_LUAD	MDH1B →	+0.492	+2.566	<.001	.003	3	2
LUNG_NSCLC_LUAD	AP1AR →	+0.436	+2.810	.001	.001	3	2
LUNG_NSCLC_LUAD	PGD →	+1.098	+2.736	<.001	.001	3	2
LUNG_NSCLC_LUAD	GCLM →	+1.226	+3.459	<.001	.002	3	2
LARGE_INTESTINE	DNAJA2 →	+0.430	+2.289	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 882 associations by consensus.

TRIM16L by PPFIA2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →