PPFIA1

Across TCGA pan-cancer cohorts, PPFIA1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPFIA1 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher PPFIA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPFIA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

SCLC, UCEC, and BLCA are the cancer types where PPFIA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.055	0.702	<.001	30	view →
UCEC	DFS	Median	All	0.924	0.616	.021	8	view →
BLCA	OS	Median	III,IV	0.859	0.346	.027	7	view →
BRCA	DFS	Median	II,III,IV	0.731	0.943	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPFIA1–SCLC (OS)

Open the SCLC breakdown →