PPFIA1

Across TCGA pan-cancer cohorts, PPFIA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPFIA1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PPFIA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPFIA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

GBM, PDAC, and UCEC are the cancer types where PPFIA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.587	0.841	<.001	25	view →
PDAC	OS	Tertile	All	0.485	0.767	.005	19	view →
UCEC	DFS	Tertile	III,IV	1.000	0.561	.049	4	view →
LUAD	DFS	Quartile	All	0.587	1.000	.012	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPFIA1–GBM (DFS)

Open the GBM breakdown →